Serveur d'exploration sur la COVID en France

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Reprint of: Practice recommendations for risk-adapted head and neck cancer radiotherapy during the COVID-19 pandemic: An ASTRO-ESTRO consensus statement.

Identifieur interne : 000761 ( Main/Exploration ); précédent : 000760; suivant : 000762

Reprint of: Practice recommendations for risk-adapted head and neck cancer radiotherapy during the COVID-19 pandemic: An ASTRO-ESTRO consensus statement.

Auteurs : David J. Thomson [Royaume-Uni] ; David Palma [Canada] ; Matthias Guckenberger [Suisse] ; Panagiotis Balermpas [Suisse] ; Jonathan J. Beitler [Géorgie (pays)] ; Pierre Blanchard [France] ; David Brizel [États-Unis] ; Wilfred Budach [Allemagne] ; Jimmy Caudell [États-Unis] ; June Corry [Australie] ; Renzo Corvo [Italie] ; Mererid Evans [Royaume-Uni] ; Adam S. Garden [États-Unis] ; Jordi Giralt [Espagne] ; Vincent Gregoire [France] ; Paul M. Harari [États-Unis] ; Kevin Harrington [Royaume-Uni] ; Ying J. Hitchcock [États-Unis] ; Jorgen Johansen [Danemark] ; Johannes Kaanders [Pays-Bas] ; Shlomo Koyfman [États-Unis] ; J A Langendijk [Pays-Bas] ; Quynh-Thu Le [États-Unis] ; Nancy Lee [États-Unis] ; Danielle Margalit [États-Unis] ; Michelle Mierzwa [États-Unis] ; Sandro Porceddu [Australie] ; Yoke Lim Soong [Singapour] ; Ying Sun [République populaire de Chine] ; Juliette Thariat [France] ; John Waldron [Canada] ; Sue S. Yom [États-Unis]

Source :

RBID : pubmed:32730830

Abstract

PURPOSE

Because of the unprecedented disruption of health care services caused by the COVID-19 pandemic, the American Society of Radiation Oncology (ASTRO) and the European Society for Radiotherapy and Oncology (ESTRO) identified an urgent need to issue practice recommendations for radiation oncologists treating head and neck cancer (HNC) in a time of limited resources and heightened risk for patients and staff.

METHODS AND MATERIALS

A panel of international experts from ASTRO, ESTRO, and select Asia-Pacific countries completed a modified rapid Delphi process. Topics and questions were presented to the group, and subsequent questions were developed from iterative feedback. Each survey was open online for 24 hours, and successive rounds started within 24 hours of the previous round. The chosen cutoffs for strong agreement (≥80%) and agreement (≥66%) were extrapolated from the RAND methodology. Two pandemic scenarios, early (risk mitigation) and late (severely reduced radiation therapy resources), were evaluated. The panel developed treatment recommendations for 5 HNC cases.

RESULTS

In total, 29 of 31 of those invited (94%) accepted, and after a replacement 30 of 30 completed all 3 surveys (100% response rate). There was agreement or strong agreement across a number of practice areas, including treatment prioritization, whether to delay initiation or interrupt radiation therapy for intercurrent SARS-CoV-2 infection, approaches to treatment (radiation dose-fractionation schedules and use of chemotherapy in each pandemic scenario), management of surgical cases in event of operating room closures, and recommended adjustments to outpatient clinic appointments and supportive care.

CONCLUSIONS

This urgent practice recommendation was issued in the knowledge of the very difficult circumstances in which our patients find themselves at present, navigating strained health care systems functioning with limited resources and at heightened risk to their health during the COVID-19 pandemic. The aim of this consensus statement is to ensure high-quality HNC treatments continue, to save lives and for symptomatic benefit.


DOI: 10.1016/j.radonc.2020.04.019
PubMed: 32730830
PubMed Central: PMC7384409


Affiliations:


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<name sortKey="Margalit, Danielle" sort="Margalit, Danielle" uniqKey="Margalit D" first="Danielle" last="Margalit">Danielle Margalit</name>
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<region type="state">Massachusetts</region>
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<name sortKey="Mierzwa, Michelle" sort="Mierzwa, Michelle" uniqKey="Mierzwa M" first="Michelle" last="Mierzwa">Michelle Mierzwa</name>
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<nlm:affiliation>Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.</nlm:affiliation>
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<name sortKey="Soong, Yoke Lim" sort="Soong, Yoke Lim" uniqKey="Soong Y" first="Yoke Lim" last="Soong">Yoke Lim Soong</name>
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<name sortKey="Sun, Ying" sort="Sun, Ying" uniqKey="Sun Y" first="Ying" last="Sun">Ying Sun</name>
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<name sortKey="Thariat, Juliette" sort="Thariat, Juliette" uniqKey="Thariat J" first="Juliette" last="Thariat">Juliette Thariat</name>
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<name sortKey="Waldron, John" sort="Waldron, John" uniqKey="Waldron J" first="John" last="Waldron">John Waldron</name>
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<wicri:regionArea>Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
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<name sortKey="Yom, Sue S" sort="Yom, Sue S" uniqKey="Yom S" first="Sue S" last="Yom">Sue S. Yom</name>
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<region type="state">Californie</region>
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<author>
<name sortKey="Guckenberger, Matthias" sort="Guckenberger, Matthias" uniqKey="Guckenberger M" first="Matthias" last="Guckenberger">Matthias Guckenberger</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich</wicri:regionArea>
<wicri:noRegion>Zurich</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Balermpas, Panagiotis" sort="Balermpas, Panagiotis" uniqKey="Balermpas P" first="Panagiotis" last="Balermpas">Panagiotis Balermpas</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich</wicri:regionArea>
<wicri:noRegion>Zurich</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Beitler, Jonathan J" sort="Beitler, Jonathan J" uniqKey="Beitler J" first="Jonathan J" last="Beitler">Jonathan J. Beitler</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiation Oncology, Emory University, Atlanta, Georgia.</nlm:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Department of Radiation Oncology, Emory University, Atlanta</wicri:regionArea>
<wicri:noRegion>Atlanta</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Blanchard, Pierre" sort="Blanchard, Pierre" uniqKey="Blanchard P" first="Pierre" last="Blanchard">Pierre Blanchard</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Radiation Oncology, Gustave Roussy Cancer Center, Villejuif, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiation Oncology, Gustave Roussy Cancer Center, Villejuif</wicri:regionArea>
<placeName>
<settlement type="city">Villejuif</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Brizel, David" sort="Brizel, David" uniqKey="Brizel D" first="David" last="Brizel">David Brizel</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Radiation Oncology, Duke Cancer Institute, Durham, North Carolina.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Radiation Oncology, Duke Cancer Institute, Durham</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Budach, Wilfred" sort="Budach, Wilfred" uniqKey="Budach W" first="Wilfred" last="Budach">Wilfred Budach</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiation Oncology, University Hospital Düsseldorf, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Radiation Oncology, University Hospital Düsseldorf</wicri:regionArea>
<wicri:noRegion>University Hospital Düsseldorf</wicri:noRegion>
<wicri:noRegion>University Hospital Düsseldorf</wicri:noRegion>
<wicri:noRegion>University Hospital Düsseldorf</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Caudell, Jimmy" sort="Caudell, Jimmy" uniqKey="Caudell J" first="Jimmy" last="Caudell">Jimmy Caudell</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Radiation Oncology, Moffitt Cancer Center, Tampa</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Corry, June" sort="Corry, June" uniqKey="Corry J" first="June" last="Corry">June Corry</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department Radiation Oncology Genesiscare, St Vincent's Hospital, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department Radiation Oncology Genesiscare, St Vincent's Hospital, Melbourne</wicri:regionArea>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Corvo, Renzo" sort="Corvo, Renzo" uniqKey="Corvo R" first="Renzo" last="Corvo">Renzo Corvo</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiation Oncology, Ospedale Policlinico San Martino and University, Genoa, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Radiation Oncology, Ospedale Policlinico San Martino and University, Genoa</wicri:regionArea>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Evans, Mererid" sort="Evans, Mererid" uniqKey="Evans M" first="Mererid" last="Evans">Mererid Evans</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Clinical Oncology, Velindre University NHS Trust, Cardiff, Wales, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Oncology, Velindre University NHS Trust, Cardiff, Wales</wicri:regionArea>
<wicri:noRegion>Wales</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Garden, Adam S" sort="Garden, Adam S" uniqKey="Garden A" first="Adam S" last="Garden">Adam S. Garden</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Giralt, Jordi" sort="Giralt, Jordi" uniqKey="Giralt J" first="Jordi" last="Giralt">Jordi Giralt</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Radiation Oncology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Radiation Oncology, Hospital Universitari Vall d'Hebron, Barcelona</wicri:regionArea>
<placeName>
<settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gregoire, Vincent" sort="Gregoire, Vincent" uniqKey="Gregoire V" first="Vincent" last="Gregoire">Vincent Gregoire</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Radiation Oncology, Centre Leon Berard, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiation Oncology, Centre Leon Berard, Lyon</wicri:regionArea>
<placeName>
<region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Harari, Paul M" sort="Harari, Paul M" uniqKey="Harari P" first="Paul M" last="Harari">Paul M. Harari</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Human Oncology, University of Wisconsin, Madison, Wisconsin.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Department of Human Oncology, University of Wisconsin, Madison</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Harrington, Kevin" sort="Harrington, Kevin" uniqKey="Harrington K" first="Kevin" last="Harrington">Kevin Harrington</name>
<affiliation wicri:level="3">
<nlm:affiliation>Division of Radiotherapy and Imaging, Institute for Cancer Research, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Radiotherapy and Imaging, Institute for Cancer Research, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hitchcock, Ying J" sort="Hitchcock, Ying J" uniqKey="Hitchcock Y" first="Ying J" last="Hitchcock">Ying J. Hitchcock</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah, Salt Lake City, Utah.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Utah</region>
</placeName>
<wicri:cityArea>Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah, Salt Lake City</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Johansen, Jorgen" sort="Johansen, Jorgen" uniqKey="Johansen J" first="Jorgen" last="Johansen">Jorgen Johansen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Oncology, Odense University Hospital, Department of Oncology, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Oncology, Odense University Hospital, Department of Oncology</wicri:regionArea>
<wicri:noRegion>Department of Oncology</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kaanders, Johannes" sort="Kaanders, Johannes" uniqKey="Kaanders J" first="Johannes" last="Kaanders">Johannes Kaanders</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Radiation Oncology, Radboudumc, Nijmegen, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiation Oncology, Radboudumc, Nijmegen</wicri:regionArea>
<placeName>
<settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Koyfman, Shlomo" sort="Koyfman, Shlomo" uniqKey="Koyfman S" first="Shlomo" last="Koyfman">Shlomo Koyfman</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Radiation Oncology, Cleveland Clinic, Cleveland, Ohio.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Department of Radiation Oncology, Cleveland Clinic, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Langendijk, J A" sort="Langendijk, J A" uniqKey="Langendijk J" first="J A" last="Langendijk">J A Langendijk</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName>
<settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Le, Quynh Thu" sort="Le, Quynh Thu" uniqKey="Le Q" first="Quynh-Thu" last="Le">Quynh-Thu Le</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Radiation Oncology, Stanford University, Palo Alto, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName>
<region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Radiation Oncology, Stanford University, Palo Alto</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Lee, Nancy" sort="Lee, Nancy" uniqKey="Lee N" first="Nancy" last="Lee">Nancy Lee</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Margalit, Danielle" sort="Margalit, Danielle" uniqKey="Margalit D" first="Danielle" last="Margalit">Danielle Margalit</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Radiation Oncology, Dana-Farber/Brigham & Women's Cancer Center, Harvard Medical School, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Radiation Oncology, Dana-Farber/Brigham & Women's Cancer Center, Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Mierzwa, Michelle" sort="Mierzwa, Michelle" uniqKey="Mierzwa M" first="Michelle" last="Mierzwa">Michelle Mierzwa</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Department of Radiation Oncology, University of Michigan, Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Porceddu, Sandro" sort="Porceddu, Sandro" uniqKey="Porceddu S" first="Sandro" last="Porceddu">Sandro Porceddu</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiation Oncology, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Radiation Oncology, Princess Alexandra Hospital, University of Queensland, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Soong, Yoke Lim" sort="Soong, Yoke Lim" uniqKey="Soong Y" first="Yoke Lim" last="Soong">Yoke Lim Soong</name>
<affiliation wicri:level="1">
<nlm:affiliation>Division of Radiation Oncology, National Cancer Centre Singapore, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Division of Radiation Oncology, National Cancer Centre Singapore</wicri:regionArea>
<wicri:noRegion>National Cancer Centre Singapore</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Sun, Ying" sort="Sun, Ying" uniqKey="Sun Y" first="Ying" last="Sun">Ying Sun</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong</wicri:regionArea>
<wicri:noRegion>Guangdong</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Thariat, Juliette" sort="Thariat, Juliette" uniqKey="Thariat J" first="Juliette" last="Thariat">Juliette Thariat</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Radiation Oncology, Centre François Baclesse, University of Normandy, Caen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiation Oncology, Centre François Baclesse, University of Normandy, Caen</wicri:regionArea>
<placeName>
<region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Waldron, John" sort="Waldron, John" uniqKey="Waldron J" first="John" last="Waldron">John Waldron</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Yom, Sue S" sort="Yom, Sue S" uniqKey="Yom S" first="Sue S" last="Yom">Sue S. Yom</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Radiation Oncology, University of California San Francisco, San Francisco, California. Electronic address: sue.yom@ucsf.edu.</nlm:affiliation>
<country>États-Unis</country>
<placeName>
<region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Radiation Oncology, University of California San Francisco, San Francisco</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology</title>
<idno type="eISSN">1879-0887</idno>
<imprint>
<date when="2020" type="published">2020</date>
</imprint>
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<front>
<div type="abstract" xml:lang="en">
<p>
<b>PURPOSE</b>
</p>
<p>Because of the unprecedented disruption of health care services caused by the COVID-19 pandemic, the American Society of Radiation Oncology (ASTRO) and the European Society for Radiotherapy and Oncology (ESTRO) identified an urgent need to issue practice recommendations for radiation oncologists treating head and neck cancer (HNC) in a time of limited resources and heightened risk for patients and staff.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>METHODS AND MATERIALS</b>
</p>
<p>A panel of international experts from ASTRO, ESTRO, and select Asia-Pacific countries completed a modified rapid Delphi process. Topics and questions were presented to the group, and subsequent questions were developed from iterative feedback. Each survey was open online for 24 hours, and successive rounds started within 24 hours of the previous round. The chosen cutoffs for strong agreement (≥80%) and agreement (≥66%) were extrapolated from the RAND methodology. Two pandemic scenarios, early (risk mitigation) and late (severely reduced radiation therapy resources), were evaluated. The panel developed treatment recommendations for 5 HNC cases.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>In total, 29 of 31 of those invited (94%) accepted, and after a replacement 30 of 30 completed all 3 surveys (100% response rate). There was agreement or strong agreement across a number of practice areas, including treatment prioritization, whether to delay initiation or interrupt radiation therapy for intercurrent SARS-CoV-2 infection, approaches to treatment (radiation dose-fractionation schedules and use of chemotherapy in each pandemic scenario), management of surgical cases in event of operating room closures, and recommended adjustments to outpatient clinic appointments and supportive care.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSIONS</b>
</p>
<p>This urgent practice recommendation was issued in the knowledge of the very difficult circumstances in which our patients find themselves at present, navigating strained health care systems functioning with limited resources and at heightened risk to their health during the COVID-19 pandemic. The aim of this consensus statement is to ensure high-quality HNC treatments continue, to save lives and for symptomatic benefit.</p>
</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="Publisher" Owner="NLM">
<PMID Version="1">32730830</PMID>
<DateRevised>
<Year>2020</Year>
<Month>09</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1879-0887</ISSN>
<JournalIssue CitedMedium="Internet">
<PubDate>
<Year>2020</Year>
<Month>Jul</Month>
<Day>27</Day>
</PubDate>
</JournalIssue>
<Title>Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology</Title>
<ISOAbbreviation>Radiother Oncol</ISOAbbreviation>
</Journal>
<ArticleTitle>Reprint of: Practice recommendations for risk-adapted head and neck cancer radiotherapy during the COVID-19 pandemic: An ASTRO-ESTRO consensus statement.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">S0167-8140(20)30200-0</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.radonc.2020.04.019</ELocationID>
<Abstract>
<AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">Because of the unprecedented disruption of health care services caused by the COVID-19 pandemic, the American Society of Radiation Oncology (ASTRO) and the European Society for Radiotherapy and Oncology (ESTRO) identified an urgent need to issue practice recommendations for radiation oncologists treating head and neck cancer (HNC) in a time of limited resources and heightened risk for patients and staff.</AbstractText>
<AbstractText Label="METHODS AND MATERIALS" NlmCategory="METHODS">A panel of international experts from ASTRO, ESTRO, and select Asia-Pacific countries completed a modified rapid Delphi process. Topics and questions were presented to the group, and subsequent questions were developed from iterative feedback. Each survey was open online for 24 hours, and successive rounds started within 24 hours of the previous round. The chosen cutoffs for strong agreement (≥80%) and agreement (≥66%) were extrapolated from the RAND methodology. Two pandemic scenarios, early (risk mitigation) and late (severely reduced radiation therapy resources), were evaluated. The panel developed treatment recommendations for 5 HNC cases.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In total, 29 of 31 of those invited (94%) accepted, and after a replacement 30 of 30 completed all 3 surveys (100% response rate). There was agreement or strong agreement across a number of practice areas, including treatment prioritization, whether to delay initiation or interrupt radiation therapy for intercurrent SARS-CoV-2 infection, approaches to treatment (radiation dose-fractionation schedules and use of chemotherapy in each pandemic scenario), management of surgical cases in event of operating room closures, and recommended adjustments to outpatient clinic appointments and supportive care.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This urgent practice recommendation was issued in the knowledge of the very difficult circumstances in which our patients find themselves at present, navigating strained health care systems functioning with limited resources and at heightened risk to their health during the COVID-19 pandemic. The aim of this consensus statement is to ensure high-quality HNC treatments continue, to save lives and for symptomatic benefit.</AbstractText>
<CopyrightInformation>Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Thomson</LastName>
<ForeName>David J</ForeName>
<Initials>DJ</Initials>
<AffiliationInfo>
<Affiliation>Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, and the Division of Cancer Sciences, The University of Manchester, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Palma</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo>
<Affiliation>Division of Radiation Oncology, Western University, London, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Guckenberger</LastName>
<ForeName>Matthias</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Balermpas</LastName>
<ForeName>Panagiotis</ForeName>
<Initials>P</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Beitler</LastName>
<ForeName>Jonathan J</ForeName>
<Initials>JJ</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiation Oncology, Emory University, Atlanta, Georgia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Blanchard</LastName>
<ForeName>Pierre</ForeName>
<Initials>P</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiation Oncology, Gustave Roussy Cancer Center, Villejuif, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Brizel</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiation Oncology, Duke Cancer Institute, Durham, North Carolina.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Budach</LastName>
<ForeName>Wilfred</ForeName>
<Initials>W</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiation Oncology, University Hospital Düsseldorf, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Caudell</LastName>
<ForeName>Jimmy</ForeName>
<Initials>J</Initials>
<AffiliationInfo>
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